RAPGEF3
RAPGEF3 (forkortelse for Rap guanine nucleotide exchange factor (GEF) 3) er et protein som hos mennesker kodes av RAPGEF3-genet.[1][2][3]
Andre navn på RAPGEF3 er: bcm910, cAMP-GEFI, EPAC og "exchange protein directly activated by cAMP 1".[4]
Referanser rediger
- ^ de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL (2000). «Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs». J Biol Chem. 275 (27): 20829–36. PMID 10777494. doi:10.1074/jbc.M001113200.
- ^ Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM (1999). «A family of cAMP-binding proteins that directly activate Rap1». Science. 282 (5397): 2275–9. PMID 9856955. doi:10.1126/science.282.5397.2275.
- ^ «Entrez Gene: RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3».
- ^ «Symbol Report: RAPGEF3». HGNC, HUGO Gene Nomenclature Commettee. Arkivert fra originalen 1. februar 2014. Besøkt 19. januar 2014.
Videre lesning rediger
- Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW (2002). «Ras and relatives--job sharing and networking keep an old family together.». Exp. Hematol. 30 (10): 1089–106. PMID 12384139. doi:10.1016/S0301-472X(02)00904-9.
- de Rooij J, Zwartkruis FJ, Verheijen MH; m.fl. (1998). «Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.». Nature. 396 (6710): 474–7. PMID 9853756. doi:10.1038/24884.
- Mei FC, Qiao J, Tsygankova OM; m.fl. (2002). «Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation.». J. Biol. Chem. 277 (13): 11497–504. PMID 11801596. doi:10.1074/jbc.M110856200.
- Qiao J, Mei FC, Popov VL; m.fl. (2002). «Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.». J. Biol. Chem. 277 (29): 26581–6. PMID 12000763. doi:10.1074/jbc.M203571200.
- Rehmann H, Prakash B, Wolf E; m.fl. (2007). «Structure and regulation of the cAMP-binding domains of Epac2.». Nat. Struct. Biol. 10 (1): 26–32. PMID 12469113. doi:10.1038/nsb878.
- Strausberg RL, Feingold EA, Grouse LH; m.fl. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Ohba Y, Kurokawa K, Matsuda M (2003). «Mechanism of the spatio-temporal regulation of Ras and Rap1». EMBO J. 22 (4): 859–69. PMC 145447 . PMID 12574122. doi:10.1093/emboj/cdg087.
- Rehmann H, Rueppel A, Bos JL, Wittinghofer A (2003). «Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac». J. Biol. Chem. 278 (26): 23508–14. PMID 12707263. doi:10.1074/jbc.M301680200.
- Hochbaum D, Tanos T, Ribeiro-Neto F; m.fl. (2003). «Activation of JNK by Epac is independent of its activity as a Rap guanine nucleotide exchanger». J. Biol. Chem. 278 (36): 33738–46. PMID 12783872. doi:10.1074/jbc.M305208200.
- Tiwari S, Felekkis K, Moon EY; m.fl. (2004). «Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis». Blood. 103 (7): 2661–7. PMID 14615375. doi:10.1182/blood-2003-06-2154.
- Ota T, Suzuki Y, Nishikawa T; m.fl. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Brandenberger R, Wei H, Zhang S; m.fl. (2005). «Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation». Nat. Biotechnol. 22 (6): 707–16. PMID 15146197. doi:10.1038/nbt971.
- Magiera MM, Gupta M, Rundell CJ; m.fl. (2005). «Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A». Biochem. J. 382 (Pt 3): 803–10. PMC 1133955 . PMID 15202935. doi:10.1042/BJ20040122.
- Enserink JM, Price LS, Methi T; m.fl. (2004). «The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin». J. Biol. Chem. 279 (43): 44889–96. PMID 15302884. doi:10.1074/jbc.M404599200.
- Keiper M, Stope MB, Szatkowski D; m.fl. (2004). «Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors». J. Biol. Chem. 279 (45): 46497–508. PMID 15319437. doi:10.1074/jbc.M403604200.
- Cullere X, Shaw SK, Andersson L; m.fl. (2005). «Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase». Blood. 105 (5): 1950–5. PMID 15374886. doi:10.1182/blood-2004-05-1987.
- Gerhard DS, Wagner L, Feingold EA; m.fl. (2004). «The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)». Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
